Chemical formula: C14H21NO15S
Chondroitin sulfate interacts in the following cases:
No effect at platelet level has been observed within the recommended dose rates. However, with rats and doses greatly in excess of the recommended 50 mg/kg/day (which would correspond to 4,000 mg in humans/day), a slight platelet antiaggregant activity has been observed. This reaction will have to be taken into account when chondroitin sulfate is used in conjunction with platelet antiaggregants (acetylsalicylic acid, dipyridamole, clopidrogel, ditazol, trifusal or ticlopidine).
There is little experience available on the use of chondroitin sulfate by patients suffering from kidney failure. Therefore, these patients must be treated with special attention.
In very rare occasions (<1/10.000) such patients have experienced cases of edema and/or water retention. This can be attributed to the osmotic effect of chondroitin sulfate.
In very rare occasions (<1/10.000) such patients have experienced cases of edema and/or water retention. This can be attributed to the osmotic effect of chondroitin sulfate.
There is no research on the use of chondroitin sulfate by pregnant women. Therefore, its use should be avoided during this period.
There is no research on the use of chondroitin sulfate by lactating women. Therefore, its use should be avoided during this period.
There is no evidence that chondroitin sulfate interferes with the ability to drive vehicles or operate machinery.
In the following table adverse reactions observed in clinical trials* (on a total of 1826 patients, out of which 1264 were treated with chondroitin sulfate) and during post marketing surveillance are listed. Adverse reactions are grouped by System Organ Class.
Within each System Organ Class, the adverse reactions are classified according to frequency of observation, using the following convention: very common (>1/10); common (>1/100, <1/10), uncommon (>1/1,.000, <1/100); rare (>1/10,000, <1/1,000); very rare (<1/10,000).
| Gastro-intestinal disorders | Rare | Gastrointestinal disorder* Epigastralgia* Nausea* Diarrhoea* |
| Skin and subcutaneous tissue disorders | Rare | Erythema Rash* Rash maculo-papular |
| Very rare | Urticaria Eczema Pruritus Allergic reaction** | |
| General disorders and administration site conditions | Very rare | Oedema |
* adverse reactions observed in clinical trials
** Cases of allergic reactions (such as angioneurotic edema) have rarely been reported
© All content on this website, including data entry, data processing, decision support tools, "RxReasoner" logo and graphics, is the intellectual property of RxReasoner and is protected by copyright laws. Unauthorized reproduction or distribution of any part of this content without explicit written permission from RxReasoner is strictly prohibited. Any third-party content used on this site is acknowledged and utilized under fair use principles.
