Chemical formula: C₂₀H₂₄ClNO Molecular mass: 329.864 g/mol PubChem compound: 2805
Cloperastine is an antitussive and antihistamine that is marketed as a cough suppressant. The precise mechanism of action of cloperastine is not fully clear, but several different biological activities have been identified for the drug, of which include: ligand of the gamma1 receptor (Ki = 20 nM) (likely an agonist), GIRK channel blocker (described as “potent”), antihistamine (Ki = 3.8 nM for the H1 receptor), and anticholinergic. Cloperastine possesses dual activity. It also acts as a mild bronchorelaxant and has antihistaminic activity, without acting on the central nervous system or the respiratory center.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| R05DB21 | Cloperastine | R Respiratory system → R05 Cough and cold preparations → R05D Cough suppressants, excl. combinations with expectorants → R05DB Other cough suppressants |
Cloperastine is an active ingredient of these brands:
Ecuador (EC)
Hong Kong (HK)Japan (JP)
Spain (ES)
Turkey (TR)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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