Coagulation factor VIII

Active ingredient description

Activated factor VIII acts as a cofactor for activated factor IX, accelerating the conversion of factor X to activated factor X (factor Xa). Haemophilia A is a sex-linked hereditary disorder of blood coagulation due to decreased levels of factor VIII:C. By replacement therapy the plasma levels of factor VIII are increased, thereby enabling a temporary correction of the factor deficiency and correction of the bleeding tendencies.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
B02BD02 Coagulation factor VIII B Blood and blood forming organs → B02 Antihemorrhagics → B02B Vitamin K and other hemostatics → B02BD Blood coagulation factors
Discover more medicines within B02BD02

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
HAEMOCTIN Powder and solvent for solution for injection Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

External identifiers

DrugBank Drug: DB13192
RxNorm Ingredient: 4257
SNOMED-CT Concept: 89165002
Coagulation factor VIII (substance)
UNII Identifier: 839MOZ74GK
ANTIHEMOPHILIC FACTOR HUMAN

Medicines

Coagulation factor VIII is an active ingredient of these brands:

United States (US)

  • (combination) WILATE as Human factor VIII

Austria (AT)

  • BERIATE
  • ELOCTA as Efmoroctocog alfa
  • ESPEROCT as TUROCTOCOG ALFA
  • HAEMOCTIN as HUMAN COAGULATION FACTOR VIII/VON WILLEBRAND FACTOR COMPLEX
  • IMMUNATE as Coagulation factor VIII and Von Willebrand factor
  • JIVI as DAMOCTOCOG ALFA PEGOL
  • NOVOEIGHT as TUROCTOCOG ALFA
  • NOVOTHIRTEEN as CATRIDECACOG
  • NUWIQ as SIMOCTOCOG ALFA
  • OCTANATE as Factor VIII (antihemophilic factor)
  • VIHUMA as SIMOCTOCOG ALFA
  • (combination) HAEMATE as Factor VIII (antihaemophilic factor)
  • (combination) VONCENTO as Human coagulation factor VIII (FVIII)
  • (combination) WILATE as Human factor VIII

Brazil (BR)

Canada (CA)

  • ADYNOVATE as ANTIHEMOPHILIC FACTOR, PEGYLATED (MW 20000) HUMAN SEQUENCE RECOMBINANT
  • ELOCTATE
  • JIVI as DAMOCTOCOG ALFA PEGOL
  • NUWIQ as SIMOCTOCOG ALFA
  • (combination) HUMATE-P
  • (combination) WILATE as Human factor VIII

Croatia (HR)

  • ELOCTA as Efmoroctocog alfa
  • EMOCLOT
  • ESPEROCT as TUROCTOCOG ALFA
  • IMMUNATE as Coagulation factor VIII and Von Willebrand factor
  • JIVI as DAMOCTOCOG ALFA PEGOL
  • NOVOEIGHT as TUROCTOCOG ALFA
  • NOVOTHIRTEEN as CATRIDECACOG
  • NUWIQ as SIMOCTOCOG ALFA
  • OCTANATE as Factor VIII (antihemophilic factor)
  • VIHUMA as SIMOCTOCOG ALFA
  • (combination) HAEMATE as Factor VIII (antihaemophilic factor)
  • (combination) VONCENTO as Human coagulation factor VIII (FVIII)
  • (combination) WILATE as Human factor VIII

Cyprus (CY)

  • ELOCTA as Efmoroctocog alfa
  • IMMUNATE as Coagulation factor VIII and Von Willebrand factor
  • JIVI as DAMOCTOCOG ALFA PEGOL
  • NOVOEIGHT as TUROCTOCOG ALFA
  • NUWIQ as SIMOCTOCOG ALFA
  • OPTIVATE
  • (combination) HAEMATE as Factor VIII (antihaemophilic factor)
  • (combination) VONCENTO as Human coagulation factor VIII (FVIII)

Ecuador (EC)

Estonia (EE)

Finland (FI)

France (FR)

Hong Kong (HK)

Ireland (IE)

Israel (IL)

Italy (IT)

Japan (JP)

Lithuania (LT)

Malta (MT)

Netherlands (NL)

  • AAFACT as EFMOROCTOCOG ALFA
  • ELOCTA as Efmoroctocog alfa
  • ESPEROCT as TUROCTOCOG ALFA
  • JIVI as DAMOCTOCOG ALFA PEGOL
  • NOVOEIGHT as TUROCTOCOG ALFA
  • NUWIQ as SIMOCTOCOG ALFA
  • OCTANATE as Factor VIII (antihemophilic factor)
  • (combination) HAEMATE as Factor VIII (antihaemophilic factor)
  • (combination) WILATE as Human factor VIII

New Zealand (NZ)

Poland (PL)

Romania (RO)

Singapore (SG)

South Africa (ZA)

Spain (ES)

Tunisia (TN)

Turkey (TR)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

 
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