Chemical formula: C₂₂H₂₅NO₆ Molecular mass: 399.443 g/mol PubChem compound: 2833
Colchicine is considered to act against the inflammatory response to urate crystals, by possibly inhibiting the migration of granulocytes into the inflamed area. Other properties of colchicine, such as interaction with the microtubules, could also contribute to the operation. Onset of action is approximately 12 hours after oral administration and is maximal after 1 to 2 days.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| L01CC | Colchicine derivatives | L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01C Plant alkaloids and other natural products |
| M04AC01 | Colchicine | M Musculo-skeletal system → M04 Antigout preparations → M04A Antigout preparations → M04AC Preparations with no effect on uric acid metabolism |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| COLCHICINE Tablet | Health Products Regulatory Authority (IE) | MPI, EU: SmPC |
Colchicine is an active ingredient of these brands:
Austria (AT)Brazil (BR)Croatia (HR)Ecuador (EC)Finland (FI)Mexico (MX)New Zealand (NZ)Poland (PL)Singapore (SG)Spain (ES)
Turkey (TR)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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