Chemical formula: C₂₁H₂₅ClO₆ Molecular mass: 408.873 g/mol PubChem compound: 9887712
Dapagliflozin is a highly potent, selective and reversible inhibitor of SGLT2. SGLT2 is the predominant transporter responsible for reabsorption of glucose from the glomerular filtrate back into the circulation. Dapagliflozin improves both fasting and post-prandial plasma glucose levels by reducing renal glucose reabsorption leading to urinary glucose excretion.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| A10BK01 | Dapagliflozin | A Alimentary tract and metabolism → A10 Drugs used in diabetes → A10B Blood glucose lowering drugs, excl. insulins → A10BK Sodium-glucose co-transporter 2 (SGLT2) inhibitors |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| FORXIGA Film-coated tablet | European Medicines Agency (EU) | MPI, EU: SmPC |
Dapagliflozin is an active ingredient of these brands:
United States (US)
Australia (AU)Austria (AT)Brazil (BR)Croatia (HR)Estonia (EE)Finland (FI)Hong Kong (HK)Ireland (IE)Japan (JP)
Lithuania (LT)Mexico (MX)
Netherlands (NL)New Zealand (NZ)Poland (PL)Romania (RO)Singapore (SG)South Africa (ZA)Spain (ES)Turkey (TR)United Kingdom (UK)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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