Dapoxetine

Chemical formula: C₂₁H₂₃NO  Molecular mass: 305.413 g/mol  PubChem compound: 71353

Therapeutic indications

Dapoxetine is indicated for:

Premature ejaculation (PE)

Population group: men, only adults (18 - 65 years old)

Dapoxetine should only be prescribed to patients who meet all the following criteria:

  • An intravaginal ejaculatory latency time (IELT) of less than two minutes; and
  • Persistent or recurrent ejaculation with minimal sexual stimulation before, on, or shortly after penetration and before the patient wishes; and
  • Marked personal distress or interpersonal difficulty as a consequence of PE; and
  • Poor control over ejaculation; and
  • A history of premature ejaculation in the majority of intercourse attempts over the prior 6 months.

Dapoxetine should be administered only as on-demand treatment before anticipated sexual activity. Dapoxetine should not be prescribed to delay ejaculation in men who have not been diagnosed with PE.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Dapoxetine is contraindicated in the following cases:

Pregnancy

Pregnancy

Lactation

Lactation

Moderate hepatic impairment, severe hepatic impairment

at least one of
Hepatic failure stage III
Hepatic failure stage IV

Heart failure, conduction abnormalities, ischemic heart disease, valvular disease, syncope

at least one of
Heart failure New York Heart Assosiation Class II
Heart failure New York Heart Assosiation Class IΙΙ
Heart failure New York Heart Assosiation Class IV
Arrhythmia
Ischemic heart disease
Heart valve disorder
Syncope attack

History of mania, history of severe depression, history of bipolar disorder

at least one of
H/O: depression
H/O: manic depressive disorder
Depressive disorder
Mania
Hypomania
Bipolar disorder

Monoamine oxidase inhibitors (MAOIs)

Monoamine oxidase inhibitors (MAOIs)

Thioridazine

Thioridazine

Serotonin reuptake inhibitors, medicinal/herbal products with serotonergic effects

at least one of

Serotonin–norepinephrine reuptake inhibitors (SNRIs)

Drugs acting on serotonin receptors
Serotonin (5HT3) antagonists
Serotonin antagonists
Serotonin antagonists and diuretics
Selective serotonin (5HT1) agonists
Linezolid
Lithium
ST. JOHN'S WORT

Potent CYP3A4 inhibitors

Strong CYP3A4 inhibitors

Depression, psychiatric disorders

at least one of
Depressive disorder
Psychotic disorder

Severe renal impairment

at least one of

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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