Deferasirox

Chemical formula: C₂₁H₁₅N₃O₄  Molecular mass: 373.362 g/mol  PubChem compound: 5493381

Therapeutic indications

Deferasirox is indicated for:

Chronic iron overload due to frequent blood transfusions in anaemia syndromes

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Deferasirox is indicated for the treatment of chronic iron overload due to frequent blood transfusions (≥7 ml/kg/month of packed red blood cells) in patients with beta thalassaemia major aged 6 years and older.

Deferasirox is also indicated for the treatment of chronic iron overload due to blood transfusions when deferoxamine therapy is contraindicated or inadequate in the following patient groups:

  • in paediatric patients with beta thalassaemia major with iron overload due to frequent blood transfusions (≥7 ml/kg/month of packed red blood cells) aged 2 to 5 years,
  • in adult and paediatric patients with beta thalassaemia major with iron overload due to infrequent blood transfusions (<7 ml/kg/month of packed red blood cells) aged 2 years and older,
  • in adult and paediatric patients with other anaemias aged 2 years and older.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Chronic iron overload in non-transfusion-dependent thalassaemia syndromes

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Deferasirox is indicated for the treatment of chronic iron overload requiring chelation therapy when deferoxamine therapy is contraindicated or inadequate in patients with non-transfusion-dependent thalassaemia syndromes aged 10 years and older.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Deferasirox is contraindicated in the following cases:

Moderate renal impairment, severe renal impairment

at least one of



Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

Severe hepatic impairment

Hepatic failure stage IV

Iron chelator therapies

at least one of
Deferoxamine
Deferiprone

Aluminium-containing antacid preparations

at least one of
Aluminium compounds
Combinations and complexes of aluminium, calcium and magnesium compounds

Lactation

Lactation

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