Deferiprone Other names: 3-hydroxy-1,2-dimethylpyridin-4-one

Chemical formula: C₇H₉NOâ‚‚  Molecular mass: 139.152 g/mol  PubChem compound: 2972

Therapeutic indications

Deferiprone is indicated for:

Iron overload in thalassaemia major

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Deferiprone monotherapy is indicated for the treatment of iron overload in patients with thalassaemia major when current chelation therapy is contraindicated or inadequate.

Deferiprone in combination with another chelator is indicated in patients with thalassaemia major when monotherapy with any iron chelator is ineffective, or when prevention or treatment of life-threatening consequences of iron overload (mainly cardiac overload) justifies rapid or intensive correction.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Deferiprone is contraindicated in the following cases:

Pregnancy

Pregnancy

Lactation

Lactation

Neutropenia, agranulocytosis

at least one of
Neutropenia
Agranulocytosis

Agranulocytosis

Agranulocytosis

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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