Difamilast

Molecular mass: 446.451 g/mol  PubChem compound: 57855696

Active ingredient description

Difamilast is an inhibitor of phosphodiesterase-4 (PDE-4). Difamilast's inhibition of PDE-4 (a major cyclic adenosine monophosphate (AMP)-metabolizing enzyme) activity leads to accumulation of intracellular cyclic AMP and decreased productions of various cytokines and chemokines. However, the specific mechanism(s) by which difamilast exerts its therapeutic action is not well defined.

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Document Type Information Source  
 ADQUEY Ointment MPI, US: SPL/PLR FDA, National Drug Code (US)

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 937782-05-3
DrugBank Drug: DB14987
KEGG Drug: D11314
PubChem Compound: 57855696
UNII Identifier: T3U32GLJ0F
DIFAMILAST

Medicines

Difamilast is an active ingredient of these brands:

Japan (JP)

United States (US)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

 
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