Dihydroergotamine

Chemical formula: C₃₃H₃₇N₅O₅  Molecular mass: 583.677 g/mol  PubChem compound: 10531

Active ingredient description

Dihydroergotamine binds with high affinity to 5-HT1Dα and 5-HT1Dβ receptors. It also binds with high affinity to serotonin 5-HT1A, 5-HT2A, and 5-HT2C receptors. The therapeutic activity of dihydroergotamine in migraine is generally attributed to the agonist effect at 5-HT1D receptors.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
N02CA01 Dihydroergotamine N Nervous system → N02 Analgesics → N02C Antimigraine preparations → N02CA Ergot alkaloids
Discover more medicines within N02CA01

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
MIGRANAL Nasal spray FDA, National Drug Code (US) MPI, US: SPL/Old
DIHYDROERGOTAMINE MESYLATE Solution for injection FDA, National Drug Code (US) MPI, US: SPL/Old

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 6190-39-2
DrugBank Drug: DB00320
KEGG Drug: D07837
PubChem Compound: 10531
RxNorm Ingredient: 3418
SNOMED-CT Concept: 387267005
Dihydroergotamine (substance)
UNII Identifier: 436O5HM03C
DIHYDROERGOTAMINE

Medicines

Dihydroergotamine is an active ingredient of these brands:

United States (US)

Austria (AT)

Brazil (BR)

  • (combination) CEFALIUM as DIHYDROERGOTAMINE MESYLATE
  • (combination) ENXAK as DIHYDROERGOTAMINE MESYLATE
  • (combination) MIGRALIV as DIHYDROERGOTAMINE MESYLATE

Canada (CA)

  • MIGRANAL as DIHYDROERGOTAMINE MESYLATE

Ecuador (EC)

  • (combination) CABEDOL as DIHYDROERGOTAMINE MESYLATE
  • (combination) MIGRAX as DIHYDROERGOTAMINE MESYLATE
  • (combination) PARALGEN MIGRA as DIHYDROERGOTAMINE MESYLATE

France (FR)

South Africa (ZA)

  • MIGRANAL as DIHYDROERGOTAMINE MESYLATE

Tunisia (TN)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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