Dobutamine

Chemical formula: C₁₈H₂₃NO₃  Molecular mass: 301.38 g/mol  PubChem compound: 36811

Therapeutic indications

Dobutamine is indicated for:

Cardiac decompensation, disturbed ventricular function

Population group: only adults (18 years old or older)

Dobutamine is indicated for patients who require a positive inotropic support in the treatment of cardiac decompensation due to depressed contractility.

In cardiogenic shock characterised by heart failure with severe hypotension and in case of septic shock dobutamine may be useful if added to dopamine in case of disturbed ventricular function, raised filling pressure of the ventricles and raised systemic resistance.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Cardiac decompensation, disturbed ventricular function

Population group: only minors (0 - 18 years old)

Dobutamine is indicated for patients who require a positive inotropic support in the treatment of cardiac decompensation due to depressed contractility.

In cardiogenic shock characterised by heart failure with severe hypotension and in case of septic shock Dobutamine may be useful if added to dopamine in case of disturbed ventricular function, raised filling pressure of the ventricles and raised systemic resistance.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Dobutamine stress echocardiography

Population group: only adults (18 years old or older)

Dobutamine may also be used for detection of myocardial ischaemia and of viable myocardium within the scope of an echocardiographic examination (dobutamine stress echocardiography), if patients cannot undergo a period of exercise or if the exercise yields no information of value.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Dobutamine is contraindicated in the following cases:

Obstruction of ventricular outflow, pericardial tamponade, constrictive pericarditis, hypertrophic obstructive cardiomyopathy

at least one of
LVOTO - Left ventricular outflow tract obstruction
Cardiac tamponade
Constrictive pericarditis
Hypertrophic obstructive cardiomyopathy
Severe stenosis of aortic valve

Hypersensitivity to dobutamine

Dobutamine allergy

Hypovolemia

at least one of
Hypovolemic shock
Hypovolemia

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Summary of Product Characteristics (SPC) 2018: DOBUTAMINE Solution for infusion
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