Dolutegravir

Chemical formula: C₂₀H₁₉F₂N₃O₅  Molecular mass: 419.379 g/mol  PubChem compound: 54726191

Therapeutic indications

Dolutegravir is indicated for:

HIV-1 infection

Population group: only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Dolutegravir is indicated in combination with other anti-retroviral medicinal products for the treatment of Human Immunodeficiency Virus (HIV) infected adults, adolescents and children of at least 4 weeks of age or older and weighing at least 3 kg.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Dolutegravir is contraindicated in the following cases:

Lactation

Lactation

Dofetilide

Dofetilide

OCT2 substrates with narrow therapeutic windows

Narrow Therapeutic Index Drugs (NTI) and additionally Substrates of organic cation transporters 2

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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