Chemical formula: C₁₉H₂₁NS Molecular mass: 295.44 g/mol PubChem compound: 5284550
Dosulepin is a tricyclic antidepressant which acts by inhibiting the re-uptake of monoamine neurotransmitters into presynaptic neurone at central nervous system, so producing a clinical antidepressant effect. Dosulepin, in common with other tricyclics, inhibits the reuptake of noradrenaline and 5-hydroxytryptamine, with a significantly greater action on the uptake of noradrenaline.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| N06AA16 | Dosulepin | N Nervous system → N06 Psychoanaleptics → N06A Antidepressants → N06AA Non-selective monoamine reuptake inhibitors |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| PROTHIADEN Capsule, hard | Health Products Regulatory Authority (IE) | MPI, EU: SmPC |
Dosulepin is an active ingredient of these brands:
Australia (AU)
France (FR)
Ireland (IE)
Japan (JP)
Netherlands (NL)
New Zealand (NZ)
Singapore (SG)South Africa (ZA)
United Kingdom (UK)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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