Doxepin

Molecular mass: 279.376 g/mol  PubChem compound: 667468

Active ingredient description

Doxepin is not a central nervous system stimulant nor a monoamine oxidase inhibitor. The current hypothesis is that the clinical effects are due, at least in part, to influences on the adrenergic activity at the synapses so that deactivation of noradrenaline by reuptake into the nerve terminals is prevented.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
D04AX01 D Dermatologicals → D04 Antipruritics, incl. antihistamines, anesthetics, etc. → D04A Antipruritics, incl. antihistamines, anesthetics, etc. → D04AX Other antipruritics
Discover more medicines within D04AX01
N06AA12 Doxepin N Nervous system → N06 Psychoanaleptics → N06A Antidepressants → N06AA Non-selective monoamine reuptake inhibitors
Discover more medicines within N06AA12

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
SILENOR Tablet FDA, National Drug Code (US) MPI, US: SPL/PLR
SINEPIN Capsule Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 1229-29-4
CAS Substance: 1668-19-5
DrugBank Drug: DB01142
KEGG Drug: D07875
PubChem Compound: 667468
RxNorm Ingredient: 3638
SNOMED-CT Concept: 372587005
Doxepin (substance)
UNII Identifier: 5ASJ6HUZ7D
DOXEPIN
UNII Identifier: F96TTB8728
CIDOXEPIN

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