Drospirenone and Estetrol

Therapeutic indications

Drospirenone and Estetrol is indicated for:

Contraception

Population group: women, only adolescents (12 years - 18 years old) , adults (18 - 65 years old)

The decision to prescribe drospirenone/estetrol should take into consideration the individual woman’s current risk factors, particularly those for venous thromboembolism (VTE), and how the risk of VTE with drospirenone/estetrol compares with other combined hormonal contraceptives (CHCs).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Drospirenone and Estetrol is contraindicated in the following cases:

Pregnancy

Pregnancy

Lactation

Lactation

Severe renal impairment, acute renal failure

at least one of

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

Severe hepatic impairment

at least one of
Hepatic failure stage IV
H/O: liver disease

Venous thromboembolism

at least one of
Thromboembolism of vein
At risk of venous thromboembolus
Deep venous thrombosis
Pulmonary embolism
Activated protein C resistance
Antithrombin III deficiency
Protein C deficiency disease
Protein S deficiency disease
Surgical procedure

Arterial thromboembolism

at least one of
Arterial embolic and thrombotic occlusion
Myocardial infarction
Angina
Cerebrovascular disease
H/O: CVA
History of transient ischemic attack
H/O: migraine
Peripheral circulatory disorder associated with diabetes mellitus
Hypertension

Liver tumour

at least one of
Neoplasm of liver
History of malignant tumor of liver

Sex steroid-influenced malignancies

Theca steroid producing cell malignant neoplasm of ovary

Undiagnosed vaginal bleeding

Observations of vaginal bleeding

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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