Chemical formula: C₃₀₅H₄₄₂N₈₈O₉₁S₈
Ecallantide is a potent (Ki=25 pM), selective, reversible inhibitor of plasma kallikrein. Ecallantide binds to plasma kallikrein and blocks its binding site, inhibiting the conversion of HMW kininogen to bradykinin.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| B06AC03 | Ecallantide | B Blood and blood forming organs → B06 Other hematological agents → B06A Other hematological agents → B06AC Drugs used in hereditary angioedema |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| KALBITOR Solution for injection | FDA, National Drug Code (US) | MPI, US: SPL/PLR |
Ecallantide is an active ingredient of these brands:
United States (US)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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