Chemical formula: C₁₂H₁₅N₅O₃ Molecular mass: 277.279 g/mol PubChem compound: 153941
Entecavir, a guanosine nucleoside analogue with activity against HBV polymerase, is efficiently phosphorylated to the active triphosphate (TP) form, which has an intracellular half-life of 15 hours. By competing with the natural substrate deoxyguanosine TP, entecavir-TP functionally inhibits the 3 activities of the viral polymerase: (1) priming of the HBV polymerase, (2) reverse transcription of the negative strand DNA from the pregenomic messenger RNA, and (3) synthesis of the positive strand HBV DNA.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| J05AF10 | Entecavir | J Antiinfectives for systemic use → J05 Antivirals for systemic use → J05A Direct acting antivirals → J05AF Nucleoside and nucleotide reverse transcriptase inhibitors |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| BARACLUDE Film-coated tablets | European Medicines Agency (EU) | MPI, EU: SmPC |
Entecavir is an active ingredient of these brands:
United States (US)Austria (AT)Brazil (BR)Canada (CA)Estonia (EE)Finland (FI)France (FR)Germany (DE)Ireland (IE)Israel (IL)Italy (IT)Japan (JP)Mexico (MX)Netherlands (NL)New Zealand (NZ)Poland (PL)Singapore (SG)Spain (ES)Turkey (TR)United Kingdom (UK)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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