Estetrol

Chemical formula: C₁₈H₂₄O₄  Molecular mass: 304.381 g/mol  PubChem compound: 27125

Therapeutic indications

Estetrol is indicated for:

Hormone replacement therapy (HRT) in hysterectomised women

Population group: women, only adults (18 - 65 years old)

Hormone replacement therapy (HRT) for oestrogen deficiency symptoms in hysterectomised postmenopausal women.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Hormone replacement therapy (HRT) in non-hysterectomised women

Population group: women, only adults (18 - 65 years old)

Hormone replacement therapy (HRT) for oestrogen deficiency symptoms in non-hysterectomised postmenopausal women with at least 12 months since last menses.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Estetrol is contraindicated in the following cases:

Pregnancy

Pregnancy

Lactation

Lactation

Fertility

Fertility

Presence or history of severe hepatic disease

at least one of
Hepatic failure stage IV
H/O: liver disease

Known, past or suspected breast cancer

at least one of
Malignant tumor of breast
Suspected breast cancer

Known, past or suspected oestrogen-dependent malignant tumours

at least one of
Malignant neoplasm of endometrium of corpus uteri
Suspected endometrial cancer
Malignant tumour of ovary
Suspected ovarian cancer
Malignant tumor of breast
Suspected breast cancer

Undiagnosed genital bleeding

Hemorrhage of genital region

Untreated endometrial hyperplasia

Endometrial hyperplasia

Previous or current venous thromboembolism

at least one of
Thromboembolism of vein
Deep venous thrombosis
Pulmonary embolism

Known thrombophilic disorders

Thrombophilia

Active or recent arterial thromboembolic disease

at least one of
Arterial thrombosis
Angina
Myocardial infarction

Porphyria

Porphyria

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