Chemical formula: C₄H₁₀FeN₂O₈S Molecular mass: 302.041 g/mol PubChem compound: 167159
Ferrous glycine sulfate interacts in the following cases:
Patients with impaired hepatic function and patients suffering from alcoholism should be treated carefully with ferrous glycine sulfate.
Patients with severe and chronic renal disease who require erythropoietin, should be treated carefully and iron should be given intravenously as oral iron is poorly absorbed in uraemic individuals.
Antacids containing oxides, hydroxides or salts of magnesium, aluminium and calcium chelate iron salts. The interval between the administrations of these two compound groups should therefore be as long as possible, the minimum time is two hours between the administrations of the antacid and iron.
The concomitant use of iron and calcium decreases the absorption of iron. Ferrous glycine sulfate should be taken apart from calcium-containing food and beverages.
When coadministered the absorption of thyroxine is inhibited by iron, which can affect the result of the treatment. The interval between the administrations of the compounds should be at least two hours.
When iron is coadministered orally with tetracycline (e.g. doxycycline), both the absorption of iron and the absorption of the tetracyclines are inhibited. The interval between the administration of Niferex and tetracyclines other than doxycycline should be at least three hours.
When iron salts are coadministered with fluoroquinolones, the absorption of the latter is significantely impaired. The absorption of norfloxacin, levofloxacin, ciprofloxacin, gatifloxacin and ofloxacin is inhibited by iron between 30 and 90%. Fluoroquinolones should be administered at least 2 h before or at least 4 h after ferrous glycine sulfate.
Medicinal products containing iron form complexes with bisphosphonates in vitro. When iron salts are coadministered with bisphosphonates, the absorption of bisphosphonates may be impaired. The time-interval between the administration of these medicinal products should be at least two hours.
Concomitant administration of iron salts with non-steroidal anti-inflammatory agents may intensify the irritant effect on the gastrointestinal mucosa.
The bioavailability of carbidopa is reduced (75%). The interval between the administrations of these compounds should be as long as possible.
Orally administered iron salts inhibit the absorption and the enterohepatic circulation of doxycycline. The combination should be avoided.
The simultaneous administration of iron sulphate and levodopa to healthy volunteers reduces the bioavailability of levodopa by 50%. The interval between the administrations of these compounds should be as long as possible.
When ferrous sulphate was given at the same time, or 1 h or 2 h before the methyldopa, the bioavailability of methyldopa was reduced 83%, 55% and 42% respectively. The interval between the administrations of these compounds should be as long as possible.
The absorption of penicillamine is reduced, as it may form chelates with iron. Penicillamine should be administered at least 2 h before ferrous glycine sulfate.
Tooth discoloration may occur during ferrous(II)-glycine-sulphate complex therapy. According to the scientific literature, this tooth discoloration can either regress spontaneously after discontinuation of the medicinal product, or has to be removed by abrasive toothpaste or by professional dental cleaning.
Patients with existing gastrointestinal disease such as inflammatory bowel disease, intestinal stricture, diverticulae, gastritis, stomach and intestinal ulcers should be treated carefully with Ferrous(II)-glycine-sulphate complex.
No known risks.
No known risks.
There are no fertility data available from the use of ferrous-glycine-sulphate complex in human.
Ferrous glycine sulfate has no or negligible influence on the ability to drive and use machines.
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