Chemical formula: C₅H₈FNO₂ Molecular mass: 132.125 g/mol PubChem compound: 450601
Fluciclovine ¹⁸F is a synthetic amino acid which is transported across mammalian cell membranes by amino acid transporters such as LAT-1 and ASCT2. The activities of LAT-1 and ASCT2 are known to be upregulated in prostate cancer, providing a mechanism for the enhanced accumulation of fluciclovine ¹⁸F in prostate cancer. Fluciclovine ¹⁸F is indicated for Positron Emission Tomography (PET) imaging to detect recurrence of prostate cancer.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| V09IX12 | V Various → V09 Diagnostic radiopharmaceuticals → V09I Tumour detection → V09IX Other diagnostic radiopharmaceuticals for tumour detection | |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| AXUMIN Solution for injection | FDA, National Drug Code (US) | MPI, US: SPL/PLR |
Fluciclovine ¹⁸F is an active ingredient of these brands:
United States (US)Austria (AT)Croatia (HR)Estonia (EE)France (FR)Ireland (IE)Japan (JP)Lithuania (LT)Poland (PL)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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