Flumazenil Other names: Flumazepil

Chemical formula: C₁₅H₁₄FN₃O₃  Molecular mass: 303.288 g/mol  PubChem compound: 3373

Therapeutic indications

Flumazenil is indicated for:

Reversal of sedation

Population group: only adults (18 years old or older)

Flumazenil is indicated for the complete or partial reversal of the central sedative effects of benzodiazepines. It may therefore be used in anaesthesia in the following situations:

  • Termination of hypnosedative effects in general anaesthesia induced and/or maintained with benzodiazepines in hospitalised patients.
  • Reversal of benzodiazepine sedation in short-term diagnostic and therapeutic procedures in ambulatory patients and hospitalised patients.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Benzodiazepine intoxication

Population group: only adults (18 years old or older)

Flumazenil is indicated for the complete or partial reversal of the central sedative effects of benzodiazepines. It may therefore be used in the intensive care in the following situations:

  • For the specific reversal of the central effects of benzodiazepines, in order to restore spontaneous respiration.
  • For diagnosis and treatment of intoxications or overdose with only or mainly benzodiazepines.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Reversal of sedation

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

For the reversal of conscious sedation induced with benzodiazepines in children above 1 year of age.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Flumazenil is contraindicated in the following cases:

Hypersensitivity to flumazenil

Population group: only adults (18 years old or older)

Flumazenil allergy

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Summary of Product Characteristics (SPC) 2020: FLUMAZENIL Solution for injection or infusion
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