Fluorouracil Other names: 5-FU 5-fluorouracil

Chemical formula: C₄H₃FN₂O₂  Molecular mass: 130.077 g/mol  PubChem compound: 3385

Therapeutic indications

Fluorouracil is indicated for:

Colorectal cancer

Population group: only adults (18 years old or older)

† Colorectal cancer

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Breast cancer

Population group: only adults (18 years old or older)

Malignant tumor of breast

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Squamous cell carcinoma of the head and neck

Population group: only adults (18 years old or older)

Fluorouracil is indicated in the treatment of:

  • inoperable locally advanced squamous cell carcinoma of the head and neck in previously untreated patients
  • locally recurrent or metastatic squamous cell carcinoma of the head and neck

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Gastric cancer, cancer of gastroesophageal junction

Population group: only adults (18 years old or older)

at least one of
Malignant tumor of stomach
Malignant neoplasm of cardio-esophageal junction of stomach

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Oesophageal cancer

Population group: only adults (18 years old or older)

Malignant tumour of oesophagus

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Pancreatic cancer

Population group: only adults (18 years old or older)

Malignant tumour of pancreas

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Pre-malignant and malignant skin lesions

Population group: only adults (18 years old or older)

Fluorouracil is used for the topical treatment of superficial pre-malignant and malignant skin lesions; keratoses including senile, actinic and arsenical forms; keratoacanthoma; Bowen’s disease; superficial basal-cell carcinoma. Deep, penetrating or nodular basal cell and squamous cell carcinomas do not usually respond to fluorouracil therapy. It should be used only as a palliative therapy in such cases where no other form of treatment is possible.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Fluorouracil is contraindicated in the following cases:

Infections

Infectious disease

Pregnancy

Pregnancy

Bone marrow depression

Bone marrow depression

Serious liver impairment

Hepatic failure stage IV

Brivudin, sorivudin

at least one of
Brivudine
SORIVUDINE

Dihydropyrimidine dehydrogenase (DPD) deficiency

Dihydrouracil dehydrogenase (NADP^+^) deficiency

Lactation

Lactation

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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