Fomepizole

Chemical formula: Câ‚„H₆Nâ‚‚  Molecular mass: 82.104 g/mol  PubChem compound: 3406

Active ingredient description

Fomepizole is a competitive inhibitor of alcohol dehydrogenase. Alcohol dehydrogenase catalyzes the oxidation of ethanol to acetaldehyde and the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites. Fomepizole is indicated as an antidote for ethylene glycol (such as antifreeze) or methanol poisoning (such as windshield washer fluid), or for use in suspected ethylene glycol or methanol ingestion, either alone or in combination with hemodialysis.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
V03AB34 Fomepizole V Various → V03 All other therapeutic products → V03A All other therapeutic products → V03AB Antidotes
Discover more medicines within V03AB34

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
ANTIZOL Solution for injection Health Products and Food Branch (CA) MPI, CA: SPM

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 7554-65-6
DrugBank Drug: DB01213
KEGG Drug: D00707
PubChem Compound: 3406
RxNorm Ingredient: 15226
SNOMED-CT Concept: 386970006
Fomepizole (substance)
UNII Identifier: 83LCM6L2BY
FOMEPIZOLE

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