Givinostat

Chemical formula: C₂₄H₂₇N₃O₄  Molecular mass: 421.2 g/mol  PubChem compound: 9804992

Active ingredient description

Givinostat is a class I and II histone deacetylase (HDAC) inhibitor that modulates the uncontrolled HDAC activity in dystrophic muscles, which contributes to the pathology of Duchenne muscular dystrophy (DMD). Givinostat HDAC inhibition has been shown to reduce muscle fiber damage, chronic muscular inflammation, fibrosis, fat deposition, and to promote mitochondrial biogenesis.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC Group Classification
M09AX14 M Musculo-skeletal system → M09 Other drugs for disorders of the musculo-skeletal system → M09A Other drugs for disorders of the musculo-skeletal system → M09AX Other drugs for disorders of the musculo-skeletal system
Discover more medicines within M09AX14

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Document Type Information Source  
 DUVYZAT Oral suspension MPI, US: SPL/PLR FDA, National Drug Code (US)
 DUVYZAT Oral suspension MPI, EU: SmPC European Medicines Agency (EU)

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 497833-27-9
DrugBank Drug: DB12645
KEGG Drug: D12742
PubChem Compound: 9804992
UNII Identifier: 5P60F84FBH
GIVINOSTAT

Medicines

Givinostat is an active ingredient of these brands:

Lithuania (LT)

United States (US)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

 
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