Glucarpidase

Active ingredient description

Glucarpidase is a recombinant bacterial enzyme that hydrolyses the carboxyl-terminal glutamate residue from folic acid and structurally related molecules such asMTX. Glucarpidase converts MTX to its inactive metabolites DAMPA and glutamate.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
V03AF09 Glucarpidase V Various → V03 All other therapeutic products → V03A All other therapeutic products → V03AF Detoxifying agents for antineoplastic treatment
Discover more medicines within V03AF09

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
VORAXAZE Powder for solution for injection FDA, National Drug Code (US) MPI, US: SPL/PLR
VORAXAZE Powder for solution for injection European Medicines Agency (EU) MPI, EU: SmPC

External identifiers

CAS Substance: 9074-87-7
DrugBank Drug: DB08898
KEGG Drug: D10260
RxNorm Ingredient: 1242127
SNOMED-CT Concept: 716225006
Glucarpidase (substance)
UNII Identifier: 2GFP9BJD79
GLUCARPIDASE

© All content on this website, including data entry, data processing, decision support tools, "RxReasoner" logo and graphics, is the intellectual property of RxReasoner and is protected by copyright laws. Unauthorized reproduction or distribution of any part of this content without explicit written permission from RxReasoner is strictly prohibited. Any third-party content used on this site is acknowledged and utilized under fair use principles.