Chemical formula: C₆H₁₃NO₅ Molecular mass: 179.171 g/mol PubChem compound: 439213
Glucosamine interacts in the following cases:
Increased effect of coumarin anticoagulants (e.g. warfarin) during concomitant treatment with glucosamine has been reported. Patients treated with coumarin anticoagulants should therefore be monitored closely when initiating or ending glucosamine therapy.
Concurrent treatment with glucosamine may increase the absorption and serum concentrations of tetracyclines, but the clinical relevance of this interaction is probably limited.
A report on exacerbated asthma symptoms triggered after initiation of glucosamine therapy has been described (symptoms resolved after withdrawal of glucosamine). Asthmatic patients starting on glucosamine should therefore be aware of potential worsening of asthma symptoms.
There are inadequate data concerning the use of glucosamine in pregnant women. From animal studies only insufficient data are available. Glucosamine should not be used during pregnancy.
There is no data available on the excretion of glucosamine in breastmilk. The use of glucosamine during breast feeding is therefore not recommended as there is no data on the safety of the child.
No studies on the effects on the ability to drive or use machines have been performed.
If dizziness or drowsiness is experienced, car driving and the operating of machinery are not recommended.
The most common adverse reactions associated with treatment with glucosamine are nausea, abdominal pain, indigestion, constipation, and diarrhoea. In addition, headache, tiredness, rash, itching, and flushing have been reported. The reported adverse reactions are usually mild and transitory.
In the table below, all causality adverse events are listed by system organ class and frequency (very common ≥1/10; common ≥1/100 to <1/10; uncommon ≥1/1,000 to <1/100; rare ≥1/10,000 to <1/1,000; very rare <1/10,000; not known (cannot be estimated from the available data)).
Common: Headache, Tiredness
Not known: Dizziness
Not known: Asthma/Asthma aggravated
Common: Nausea, Abdominal pain, Indigestion, Diarrhoea, Constipation
Not known: Vomiting
Uncommon: Rash, Itching, Flushing
Not known: Angioedema, Urticaria
Not known: Diabetes mellitus inadequate control, Hypercholesterolaemia
Not known: Oedema/Peripheral oedema
Cases of hypercholesterolemia, asthma, aggravated and diabetes mellitus inadequate control have been reported, but causality has not been established.
Dolenio may cause Hepatic enzyme elevation and rarely jaundice.
Blood glucose control worsened in patients with diabetes mellitus. Frequency not known.
© All content on this website, including data entry, data processing, decision support tools, "RxReasoner" logo and graphics, is the intellectual property of RxReasoner and is protected by copyright laws. Unauthorized reproduction or distribution of any part of this content without explicit written permission from RxReasoner is strictly prohibited. Any third-party content used on this site is acknowledged and utilized under fair use principles.
