Guanethidine

Chemical formula: C₁₀H₂₂N₄  Molecular mass: 198.309 g/mol  PubChem compound: 3518

Active ingredient description

Guanethidine is a antihypertensive drug. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues. It is taken up by norepinephrine transporters. It becomes concentrated in norepinephrine transmitter vesicles, replacing norepinephrine in these vesicles.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
C02CC02 Guanethidine C Cardiovascular system → C02 Antihypertensives → C02C Antiadrenergic agents, peripherally acting → C02CC Guanidine derivatives
Discover more medicines within C02CC02
S01EX01 Guanethidine S Sensory organs → S01 Ophthalmologicals → S01E Antiglaucoma preparations and miotics → S01EX Other antiglaucoma preparations
Discover more medicines within S01EX01

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 55-65-2
CAS Substance: 645-43-2
DrugBank Drug: DB01170
KEGG Drug: D02237
PubChem Compound: 3518
RxNorm Ingredient: 5036
SNOMED-CT Concept: 387456007
Guanethidine (substance)
UNII Identifier: ZTI6C33Q2Q
GUANETHIDINE
 
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