Guanfacine

Chemical formula: C₉H₉Cl₂N₃O  Molecular mass: 246.093 g/mol  PubChem compound: 3519

Active ingredient description

Guanfacine is a selective alpha2A-adrenergic receptor agonist in that it has 15-20 times higher affinity for this receptor subtype than for the alpha2B or alpha2C subtypes. Guanfacine is a non-stimulant. The mode of action of guanfacine in ADHD is not fully established.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
C02AC02 Guanfacine C Cardiovascular system → C02 Antihypertensives → C02A Antiadrenergic agents, centrally acting → C02AC Imidazoline receptor agonists
Discover more medicines within C02AC02

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
INTUNIV Prolonged-release tablet European Medicines Agency (EU) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 29110-47-2
DrugBank Drug: DB01018
KEGG Drug: D08031
PubChem Compound: 3519
RxNorm Ingredient: 40114
SNOMED-CT Concept: 372507007
Guanfacine (substance)
UNII Identifier: 30OMY4G3MK
GUANFACINE

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