Hepatitis A, inactivated vaccine

Mechanism of action

Hepatitis A vaccine elicits circulating neutralising antibodies to Hepatitis A virus sufficient to confer protection against the virus.

Pharmacodynamic properties

Inactivated virus of a strain which was originally derived by further serial passage of a proven attenuated strain. The virus is grown, harvested, highly purified, formalin inactivated, and then adsorbed onto amorphous aluminum hydroxyphosphate sulphate.

Pharmacokinetic properties

Evaluation of pharmacokinetic properties is not required for vaccines.

Preclinical safety data

No preclinical safety testing was performed using the vaccine.

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