Chemical formula: C₅H₉N₃ Molecular mass: 111.145 g/mol PubChem compound: 774
Histamine/IL-2 is an immunotherapy which aims to induce immune-mediated destruction of residual myeloid leukaemic cells and thereby to prevent relapse of leukaemia. The role of histamine is to protect lymphocytes, in particular NK cells and T cells, which are responsible for the immune-mediated destruction of residual leukaemic cells.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| L03AX14 | Histamine dihydrochloride | L Antineoplastic and immunomodulating agents → L03 Immunostimulants → L03A Immunostimulants → L03AX Other immunostimulants |
| V04CG03 | Histamine phosphate | V Various → V04 Diagnostic agents → V04C Other diagnostic agents → V04CG Tests for gastric secretion |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| CEPLENE Solution for injection | European Medicines Agency (EU) | MPI, EU: SmPC |
Histamine is an active ingredient of these brands:
Austria (AT)
Canada (CA)
Croatia (HR)
Estonia (EE)
Finland (FI)
France (FR)
Japan (JP)
Lithuania (LT)
Poland (PL)
Romania (RO)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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