Chemical formula: C₂₂H₁₈FN₇O Molecular mass: 415.432 g/mol PubChem compound: 11625818
Idelalisib inhibits phosphatidylinositol 3-kinase p110δ (PI3Kδ), which is hyperactive in B-cell malignancies and is central to multiple signalling pathways that drive proliferation, survival, homing, and retention of malignant cells in lymphoid tissues and bone marrow. Idelalisib induces apoptosis and inhibits proliferation in cell lines derived from malignant B-cells and in primary tumour cells.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| L01EM01 | L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01E Protein kinase inhibitors → L01EM Phosphatidylinositol-3-kinase (Pi3K) inhibitors | |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| ZYDELIG Film-coated tablet | European Medicines Agency (EU) | MPI, EU: SmPC |
Idelalisib is an active ingredient of these brands:
United States (US)Australia (AU)Austria (AT)Canada (CA)Cyprus (CY)Ecuador (EC)Estonia (EE)France (FR)Ireland (IE)Lithuania (LT)Netherlands (NL)New Zealand (NZ)Poland (PL)Spain (ES)United Kingdom (UK)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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