Imipenem, Cilastatin and Relebactam

Therapeutic indications

Imipenem, Cilastatin and Relebactam is indicated for:

Hospital-acquired pneumonia

Population group: only adults (18 years old or older)

Imipenem/cilastatin/relebactam combination is indicated for treatment of hospital-acquired pneumonia (HAP), including ventilator associated pneumonia (VAP), in adults.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Infections due to aerobic Gram-negative organisms

Population group: only adults (18 years old or older)

Imipenem/cilastatin/relebactam combination is indicated for the treatment of infections due to aerobic Gram-negative organisms in adults with limited treatment options.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Complicated urinary tract infections

Population group: only adults (18 years old or older)

Imipenem/cilastatin/relebactam combination is indicated in patients 18 years of age and older who have limited or no alternative treatment options, for the treatment of complicated urinary tract infections (cUTI), including pyelonephritis, caused by the following susceptible gram-negative microorganisms: Enterobacter cloacae, Escherichia coli, Klebsiella aerogenes, Klebsiella pneumoniae, and Pseudomonas aeruginosa.

Approval of this indication is based on limited clinical safety and efficacy data for imipenem/cilastatin/relebactam.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Complicated intra-abdominal infections

Population group: only adults (18 years old or older)

Imipenem/cilastatin/relebactam combination is indicated in patients 18 years of age and older who have limited or no alternative treatment options for the treatment of complicated intra-abdominal infections (cIAI) caused by the following susceptible gram-negative microorganisms: Bacteroides caccae, Bacteroides fragilis, Bacteroides ovatus, Bacteroides stercoris, Bacteroides thetaiotaomicron, Bacteroides uniformis, Bacteroides vulgatus, Citrobacter freundii, Enterobacter cloacae, Escherichia coli, Fusobacterium nucleatum, Klebsiella aerogenes, Klebsiella oxytoca, Klebsiella pneumoniae, Parabacteroides distasonis, and Pseudomonas aeruginosa.

Approval of this indication is based on limited clinical safety and efficacy data for imipenem/cilastatin/relebactam.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Imipenem, Cilastatin and Relebactam is contraindicated in the following cases:

Lactation

Lactation

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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