Imipramine

Molecular mass: 280.407 g/mol  PubChem compound: 3696

Active ingredient description

Imipramine is a tricyclic antidepressant and has several pharmacological actions including alpha-adrenolytic, antihistamine, anticholinergic and 5HT-receptor blocking properties. However, the main therapeutic activity is believed to be inhibition of the neuronal re-uptake of noradrenaline and 5HT. Imipramine is a so-called “mixed” re-uptake blocker, i.e. it inhibits the reuptake of NA and 5HT to about the same extent.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
N06AA02 Imipramine N Nervous system → N06 Psychoanaleptics → N06A Antidepressants → N06AA Non-selective monoamine reuptake inhibitors
Discover more medicines within N06AA02

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
IMIPRANIME Sugar-coated tablet Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
TOFRANIL Sugar-coated tablet FDA, National Drug Code (US) MPI, US: SPL/Old

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 50-49-7
DrugBank Drug: DB00458
KEGG Drug: D08070
PubChem Compound: 3696
RxNorm Ingredient: 5691
SNOMED-CT Concept: 372718005
Imipramine (substance)
UNII Identifier: OGG85SX4E4
IMIPRAMINE

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