Isosorbide mononitrate

Chemical formula: C₆H₉NO₆  Molecular mass: 191.139 g/mol  PubChem compound: 27661

Active ingredient description

Isosorbide mononitrate is an organic nitrate, which, in common with other cardioactive nitrates, is a vasodilator. It produces decreased left and right ventricular end-diastolic pressures to a greater extent than the decrease in systemic arterial pressure, thereby reducing afterload and especially the preload of the heart.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
C01DA14 Isosorbide mononitrate C Cardiovascular system → C01 Cardiac therapy → C01D Vasodilators used in cardiac diseases → C01DA Organic nitrates
Discover more medicines within C01DA14

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
NYZAMAC Prolonged-release capsule, hard Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
ISOSORBIDE MONONITRATE / CARMIL / MONOMIL Tablet Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 16051-77-7
DrugBank Drug: DB01020
KEGG Drug: D00630
PubChem Compound: 27661
RxNorm Ingredient: 28004
SNOMED-CT Concept: 386854005
Isosorbide mononitrate (substance)
UNII Identifier: LX1OH63030
ISOSORBIDE MONONITRATE

Medicines

Isosorbide mononitrate is an active ingredient of these brands:

United States (US)

Albania (AL)

Australia (AU)

Austria (AT)

Brazil (BR)

Canada (CA)

Croatia (HR)

Cyprus (CY)

Ecuador (EC)

Estonia (EE)

Finland (FI)

Germany (DE)

Hong Kong (HK)

Ireland (IE)

Israel (IL)

Italy (IT)

Japan (JP)

Lithuania (LT)

Malta (MT)

Mexico (MX)

Netherlands (NL)

New Zealand (NZ)

Poland (PL)

Romania (RO)

Singapore (SG)

South Africa (ZA)

Spain (ES)

Turkey (TR)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

 
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