Ketotifen Other names: Ketotifen fumarate

Chemical formula: C₁₉H₁₉NOS  Molecular mass: 309.425 g/mol  PubChem compound: 3827

Active ingredient description

Ketotifen is a histamine H1-receptor antagonist. In vivo animal studies and in vitro studies suggest the additional activities of mast cell stabilisation and inhibition of infiltration, activation and degranulation of eosinophils.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
R06AX17 Ketotifen R Respiratory system → R06 Antihistamines for systemic use → R06A Antihistamines for systemic use → R06AX Other antihistamines for systemic use
Discover more medicines within R06AX17
S01GX08 Ketotifen S Sensory organs → S01 Ophthalmologicals → S01G Decongestants and antiallergics → S01GX Other antiallergics
Discover more medicines within S01GX08

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
ZADITEN Eye drops, solution Health Products Regulatory Authority (IE) MPI, EU: SmPC
ZADITEN Tablet Health Products Regulatory Authority (IE) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 34580-13-7
CAS Substance: 34580-14-8
DrugBank Drug: DB00920
KEGG Drug: D01332
PubChem Compound: 3827
RxNorm Ingredient: 6146
SNOMED-CT Concept: 372642003
Ketotifen (substance)
UNII Identifier: X49220T18G


Ketotifen is an active ingredient of these brands:

Albania (AL)

Austria (AT)

Brazil (BR)

Canada (CA)

Cyprus (CY)

Ecuador (EC)

Estonia (EE)

Finland (FI)

France (FR)

Hong Kong (HK)

Ireland (IE)

Israel (IL)

Italy (IT)

Japan (JP)

Mexico (MX)

Netherlands (NL)

New Zealand (NZ)

Nigeria (NG)

Poland (PL)

Romania (RO)


Singapore (SG)

South Africa (ZA)

Spain (ES)

Tunisia (TN)

Turkey (TR)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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