Lamivudine and Abacavir

Chemical formula: C₂₂H₂₉N₉O₄S Molecular mass: 515.591 g/mol

Therapeutic indications

Lamivudine and Abacavir is indicated for:

Human immunodeficiency virus infection

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 - 65 years old)

Abacavir/lamivudine combination is indicated in antiretroviral combination therapy for the treatment of Human Immunodeficiency Virus (HIV) infection in adults, adolescents and children weighing at least 25 kg.

Before initiating treatment with abacavir, screening for carriage of the HLA-B*5701 allele should be performed in any HIV-infected patient, irrespective of racial origin. Abacavir should not be used in patients known to carry the HLA-B*5701 allele.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

600 mg of abacavir and 300 mg lamivudine once daily

Contraindications

Lamivudine and Abacavir is contraindicated in the following cases:

Lactation

Severe renal impairment

at least one of

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

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