Letermovir

Chemical formula: C₂₉H₂₈F₄N₄O₄  Molecular mass: 572.561 g/mol 

Therapeutic indications

Letermovir is indicated for:

Prophylaxis of cytomegalovirus (CMV) in CMV-seropositive recipients [R+] of an allogeneic haematopoietic stem cell transplant

Population group: only adults (18 years old or older)

Letermovir is indicated for prophylaxis of cytomegalovirus (CMV) reactivation and disease in adult and paediatric patients weighing at least 15 kg who are CMV-seropositive recipients [R+] of an allogeneic haematopoietic stem cell transplant (HSCT).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Prophylaxis of cytomegalovirus (CMV) in CMV-seronegative recipients of a kidney transplant from a CMV-seropositive donor [D+/R-]

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Letermovir is indicated for prophylaxis of CMV disease in CMV-seronegative adult and paediatric patients weighing at least 40 kg who have received a kidney transplant from a CMV-seropositive donor [D+/R-].

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Letermovir is contraindicated in the following cases:

Pimozide

Pimozide

Ergot alkaloids

Ergot alkaloids

Lactation

Lactation

St. John's wort

Hypericum perforatum (St John's Wort)

Concomitant use of letermovir and cyclosporine with dabigatran, atorvastatin, simvastatin, rosuvastatin or pitavastatin

at least one of
Dabigatran
Simvastatin
Pitavastatin
Rosuvastatin
Atorvastatin
and additionally Ciclosporin

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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