Chemical formula: C₅₉H₈₄N₁₆O₁₂ Molecular mass: 1,209.398 g/mol
Leuprorelin is inactive when given orally due to poor membrane permeability and an almost complete inactivation by intestinal proteolytic enzymes. Leuprorelin has potent LHRH agonist properties when given during short-term and intermittent therapy, however, when administered in a continuous, nonpulsatile manner, LHRH analogs induce inhibition of gonadotropin secretion and suppression of testicular steroidogenesis.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| L02AE02 | Leuprorelin | L Antineoplastic and immunomodulating agents → L02 Endocrine therapy → L02A Hormones and related agents → L02AE Gonadotropin releasing hormone analogues |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| PROSTAP 3 DCS Powder and solvent for suspension for injection in pre-filled syringe | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC | |
| LUTRATE DEPOT Powder and solvent for prolonged-release suspension for injection | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC |
Leuprorelin is an active ingredient of these brands:
Australia (AU)
Austria (AT)
Brazil (BR)Canada (CA)
Croatia (HR)Ecuador (EC)Estonia (EE)Finland (FI)
France (FR)Hong Kong (HK)Ireland (IE)Lithuania (LT)New Zealand (NZ)
Poland (PL)
Romania (RO)Spain (ES)Turkey (TR)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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