Lidocaine Other names: Lignocaine

Chemical formula: C₁₄H₂₂N₂O  Molecular mass: 234.337 g/mol  PubChem compound: 3676

Active ingredient description

Lidocaine, like other local anaesthetics, causes a reversible blockade of impulse propagation along nerve fibres by preventing the inward movement of sodium ions through the nerve membrane. Local anaesthetics of the amide-type are thought to act within the sodium channels of the nerve membrane.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
C01BB01 Lidocaine C Cardiovascular system → C01 Cardiac therapy → C01B Antiarrhythmics, class I and III → C01BB Antiarrhythmics, class Ib
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C05AD01 Lidocaine C Cardiovascular system → C05 Vasoprotectives → C05A Agents for treatment of hemorrhoids and anal fissures for topical use → C05AD Local anesthetics
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D04AB01 Lidocaine D Dermatologicals → D04 Antipruritics, incl. antihistamines, anesthetics, etc. → D04A Antipruritics, incl. antihistamines, anesthetics, etc. → D04AB Anesthetics for topical use
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N01BB02 Lidocaine N Nervous system → N01 Anesthetics → N01B Anesthetics, local → N01BB Amides
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R02AD02 Lidocaine R Respiratory system → R02 Throat preparations → R02A Throat preparations → R02AD Anesthetics, local
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S01HA07 Lidocaine S Sensory organs → S01 Ophthalmologicals → S01H Local anesthetics → S01HA Local anesthetics
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S02DA01 Lidocaine S Sensory organs → S02 Otologicals → S02D Other otologicals → S02DA Analgesics and anesthetics
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Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
XYLOCAINE Spray Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

3D molecular structure

3D representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 137-58-6
CAS Substance: 6108-05-0
CAS Substance: 73-78-9
DrugBank Drug: DB00281
KEGG Drug: D00358
PubChem Compound: 3676
RxNorm Ingredient: 6387
SNOMED-CT Concept: 387480006
Lidocaine (substance)
UNII Identifier: 98PI200987

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