Lifitegrast

Chemical formula: C₂₉H₂₄Cl₂N₂O₇S  Molecular mass: 615.48 g/mol  PubChem compound: 11965427

Active ingredient description

Lifitegrast is a lymphocyte function-associated antigen-1 (LFA-1) antagonist. It binds to the integrin LFA-1, a cell surface protein found on leukocytes and blocks the interaction of LFA-1 with its cognate ligand intercellular adhesion molecule-1 (ICAM-1). ICAM-1 may be overexpressed in corneal and conjunctival tissues in DED.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
S01XA25 S Sensory organs → S01 Ophthalmologicals → S01X Other ophthalmologicals → S01XA Other ophthalmologicals
Discover more medicines within S01XA25

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
XIIDRA Οphthalmic solution FDA, National Drug Code (US) MPI, US: SPL/PLR

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 1025967-78-5
DrugBank Drug: DB11611
KEGG Drug: D10374
PubChem Compound: 11965427
RxNorm Ingredient: 1801820
SNOMED-CT Concept: 720489009
Lifitegrast (substance)
UNII Identifier: 038E5L962W
LIFITEGRAST

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