Lorlatinib

Chemical formula: C₂₁H₁₉FN₆O₂  Molecular mass: 406.421 g/mol  PubChem compound: 71731823

Therapeutic indications

Lorlatinib is indicated for:

Non-small cell lung cancer (NSCLC) with anaplastic lymphoma kinase (ALK)-positive

Lorlatinib as monotherapy is indicated for the treatment of adult patients with anaplastic lymphoma kinase (ALK)-positive advanced non-small cell lung cancer (NSCLC) whose disease has progressed after:

  • alectinib or ceritinib as the first ALK tyrosine kinase inhibitor (TKI) therapy; or
  • crizotinib and at least one other ALK TKI.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Lorlatinib is contraindicated in the following cases:

Strong CYP3A4/5 inducers

at least one of
Strong potency CYP3A4 inducers
Cytochrome P-450 CYP3A5 strong inducers

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