Lormetazepam

Chemical formula: C₁₆H₁₂Cl₂N₂O₂  Molecular mass: 335.185 g/mol  PubChem compound: 13314

Pharmacodynamic properties

Lormetazepam is a benzodiazepine with anxiolytic, muscle relaxant, sedative and hypnotic properties. Clinical studies have shown minimal effects on REM sleep and on psychomotor performance on the day after treatment with lormetazepam.

Pharmacokinetic properties

Lormetazepam is rapidly absorbed from the gastrointestinal tract and is metabolised by a simple one-step process to a pharmacologically inactive glucuronide. There are no major metabolites and little risk of accumulation. Lormetazepam has a terminal phase half life of about 11 hours.

Preclinical safety data

Fertility in male and female rats was not adversely affected by oral lormetazepam.

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