Chemical formula: C₂₀H₁₄Cl₃F₆N₃O₃S Molecular mass: 594.973 g/mol PubChem compound: 76959255
Lotilaner is a gamma-aminobutyric acid (GABA)-gated chloride channel inhibitor selective for mites. Inhibition of these GABA chloride channels causes a paralytic action in the target organism leading to its death. Lotilaner is not an inhibitor of mammalian GABA mediated chloride channels when tested at up to 30 µM (18 µg/mL) in vitro (approximately 1100 times the RHOD).
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| XDEMVY Ophthalmic solution | FDA, National Drug Code (US) | MPI, US: SPL/PLR |
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