Macitentan

Chemical formula: C₁₉H₂₀Br₂N₆O₄S  Molecular mass: 588.273 g/mol  PubChem compound: 16004692

Therapeutic indications

Macitentan is indicated for:

Pulmonary arterial hypertension (PAH) functional class (FC) II to III

Population group: only adults (18 years old or older)

Macitentan, as monotherapy or in combination, is indicated for the long-term treatment of pulmonary arterial hypertension (PAH) in adult patients of WHO Functional Class (FC) II to III.

Efficacy has been shown in a PAH population including idiopathic and heritable PAH, PAH associated with connective tissue disorders, and PAH associated with corrected simple congenital heart disease.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Macitentan is contraindicated in the following cases:

Pregnancy

Pregnancy

Lactation

Lactation

Severe hepatic impairment

Hepatic failure stage IV

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