Chemical formula: C₁₁H₂₁N Molecular mass: 167.291 g/mol PubChem compound: 4032
Pregnancy Category C.
Animal reproduction studies have not been conducted with mecamylamine. It is not known whether mecamylamine can cause fetal harm when given to a pregnant woman or can affect reproductive capacity. Mecamylamine should be given to a pregnant woman only if clearly needed.
Because of the potential for serious adverse reactions in nursing infants from mecamylamine, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Long-term studies in animals have not been performed to evaluate the effects upon fertility, mutagenic or carcinogenic potential of mecamylamine.
The following adverse reactions have been reported and within each category are listed in order of decreasing severity.
Gastrointestinal: Ileus, constipation (sometimes preceded by small, frequent liquid stools), vomiting, nausea, anorexia, glossitis and dryness of mouth.
Cardiovascular: Orthostatic dizziness and syncope, postural hypotension.
Nervous System/Psychiatric: Convulsions, choreiform movements, mental aberrations, tremor, and paresthesias.
Respiratory: Interstitial pulmonary edema and fibrosis.
Urogenital: Urinary retention, impotence, decreased libido.
Special Senses: Blurred vision, dilated pupils.
Miscellaneous: Weakness, fatigue, sedation.
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