Metformin and Sitagliptin is indicated for:
Population group: only adults (18 years old or older)
For adult patients with type 2 diabetes mellitus:
Sitagliptin/metformin combination is indicated as an adjunct to diet and exercise to improve glycaemic control in patients inadequately controlled on their maximal tolerated dose of metformin alone or those already being treated with the combination of sitagliptin and metformin.
Sitagliptin/metformin combination is indicated in combination with a sulphonylurea (i.e., triple combination therapy) as an adjunct to diet and exercise in patients inadequately controlled on their maximal tolerated dose of metformin and a sulphonylurea.
Sitagliptin/metformin combination is indicated as triple combination therapy with a peroxisome proliferator-activated receptor gamma (PPAR) agonist (i.e., a thiazolidinedione) as an adjunct to diet and exercise in patients inadequately controlled on their maximal tolerated dose of metformin and a PPAR agonist.
Sitagliptin/metformin combination is also indicated as add-on to insulin (i.e., triple combination therapy) as an adjunct to diet and exercise to improve glycaemic control in patients when stable dose of insulin and metformin alone do not provide adequate glycaemic control.
For this indication, competent medicine agencies globally authorize below treatments (click for details):
Metformin and Sitagliptin is contraindicated in the following cases:
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