Nicardipine

Chemical formula: C₂₆H₂₉N₃O₆ Molecular mass: 479.525 g/mol PubChem compound: 4474

Therapeutic indications

Nicardipine is indicated for:

Prophylaxis of chronic stable angina

Population group: only adults (18 - 65 years old)

Nicardipine is indicated in adults for the prophylaxis of patients with chronic stable angina.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

60-120 mg in 3 divided doses daily

Hypertension

Population group: only adults (18 - 65 years old)

For the treatment of hypertension considered to be mild to moderate in severity.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

60-120 mg in 3 divided doses daily

Prophylaxis of chronic stable angina

Population group: only elderly (65 years old or older)

Nicardipine is indicated in adults for the prophylaxis of patients with chronic stable angina.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

60 mg in 3 divided doses daily

Hypertension

Population group: only elderly (65 years old or older)

For the treatment of hypertension considered to be mild to moderate in severity.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

60 mg in 3 divided doses daily

Malignant hypertension, hypertensive encephalopathy, dissection of aorta, severe pre-eclampsia, postoperative hypertension

Population group: only adults (18 - 65 years old)

Nicardipine solution for injection is indicated for the treatment of acute life-threatening hypertension, particularly in the event of:

Malignant arterial hypertension/Hypertensive encephalopathy.
Aortic dissection, when short acting beta-blocker therapy is not suitable, or in combination with a beta-blocker when beta-blockade alone is not effective.
Nicardipine is also indicated for the treatment of post-operative hypertension.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

2-5 mg/h

Malignant hypertension, hypertensive encephalopathy, dissection of aorta, postoperative hypertension

Population group: only elderly (65 years old or older)

Nicardipine solution for injection is indicated for the treatment of acute life-threatening hypertension, particularly in the event of:

Malignant arterial hypertension/Hypertensive encephalopathy.
Aortic dissection, when short acting beta-blocker therapy is not suitable, or in combination with a beta-blocker when beta-blockade alone is not effective.
Nicardipine is also indicated for the treatment of post-operative hypertension.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

0.5-5 mg/h

Severe pre-eclampsia

Population group: women, only adults (18 - 65 years old)

Severe pre-eclampsia, when other intravenous antihypertensive agents are not recommended or are contra-indicated.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

0.5-15 mg/h

Contraindications

Nicardipine is contraindicated in the following cases:

Pregnancy

Pregnancy

Lactation

Lactation

Cardiogenic shock, unstable angina, clinically significant aortic stenosis, unstable angina, recent myocardial infarction

at least one of

Cardiogenic shock
Critical stenosis of aortic valve
Preinfarction syndrome
Recent myocardial infarction

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