Chemical formula: C₈H₉N₃O₄ Molecular mass: 211.177 g/mol PubChem compound: 47528
Nicorandil is a derivative of the niacinamide that is structurally combined with an organic nitrate. It provides a dual mode of action leading to relaxation of vascular smooth muscle. Nicorandil is a potassium-channel opener that causes vasodilatation of arterioles and large coronary arteries. Its nitrate-like properties produce venous vasodilation through stimulation of guanylate cyclase. Nicorandil has a direct effect on coronary arteries without leading to a steal phenomenon. The overall action improves blood flow to post-stenotic regions and the oxygen balance in the myocardium.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| C01DX16 | Nicorandil | C Cardiovascular system → C01 Cardiac therapy → C01D Vasodilators used in cardiac diseases → C01DX Other vasodilators used in cardiac diseases |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| IKOREL Tablet | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC |
Nicorandil is an active ingredient of these brands:
France (FR)Ireland (IE)Japan (JP)Netherlands (NL)New Zealand (NZ)Turkey (TR)United Kingdom (UK)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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