Chemical formula: C₂₀H₂₆O₂ Molecular mass: 298.419 g/mol PubChem compound: 6230
Norethisterone interacts in the following cases:
Special care should be taken when progestogens are administered with other drugs which also cause fluid retention, such as NSAIDs and vasodilators.
Strong and moderate CYP3A4 inhibitors such as azole antifungals (e.g. itraconazole, voriconazole, fluconazole), verapamil, macrolides (e.g. clarithromycin, erythromycin), diltiazem and grapefruit juice can increase plasma concentrations of the estrogen or the progestin or both.
When progestogens used in combination with cytotoxic drugs, it is possible that progestogens may reduce the haematological toxicity of chemotherapy.
Aminoglutethimide has been reported to decrease plasma levels of some progestogens.
Concurrent administration of ciclosporin and norethisterone has been reported to lead to increased plasma ciclosporin levels and/or decreased plasma norethisterone levels.
The administration of norethisterone during pregnancy is contraindicated.
Norethisterone can pass into breast milk and therefore should be avoided during lactation.
Norethisterone has no influence on the ability to drive and use machines.
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