Chemical formula: C₁₀H₈N₆O Molecular mass: 228.21 g/mol PubChem compound: 57697
Pemirolast potassium is a mast cell stabilizer that inhibits the in vivo Type I immediate hypersensitivity reaction. In vitro and in vivo studies have demonstrated that pernirolast inhibits the antigen-induced release of inflanunatory mediators (e.g., histamine, leukotriene C4, D4, E4) from human mast cells. In addition, pemirolast inhibits the chemotaxis of eosinophils into ocular tissue and blocks the release of mediators from human easinophils. Although the precise mechanism of action is unknown, the drug has been reported to prevent calcium influx into mast cells upon antigen stimulation.
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| ALAMAST Ophthalmic solution | Web Search | MPI, US: SPL/Old |
Pemirolast is an active ingredient of these brands:
Hong Kong (HK)
Japan (JP)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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